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A-M Systems電生理系列產品
A-M Systems是美國知名科研儀器制造商,其產品以優秀的性能及合理的價格深受廣大科研人員歡迎并在Science, Nature, Neuroscience等權威期刊上引用。產品覆蓋膜片鉗放大器、細胞內/外放大器、刺激信號發生器、信號采集等電生理實驗必備儀器及其配件。
膜片鉗放大器

Model 2400 膜片鉗放大器
產品特點:
l 全功能膜片鉗,實現全細胞記錄及和膜片記錄
l 可切換的雙阻反饋探頭
l 提供電容、電阻、及全細胞補償機制
l 四極貝塞爾低通濾波器
l 可自發測試信號
l 內置液晶屏顯示關鍵數據
l 前面板操作記錄可報表輸出
l 三年質保
引用案例:
l Smith AJ, Sugita S, and Charlton MP. (2010) Cholesterol-dependent kinase activity regulates transmitter release from cerebellar synapses. J Neuroscience 30(17): 6116-6121
l Del Negro CA et al. (2009) Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J Physiology 587: 1217-1231
l Olsen SR and Wilson RI. (2008) Lateral presynaptic inhibition mediates gain control in an olfactory circuit. Nature 452:956-960
l Yao CA, Ingell R, and Carlson JR (2005) Chemosensory coding by neurons in the coeloconic sensilla of the Drosophila Antenna. J Neuroscience 25(37): 8359-8367
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細胞內放大器

Model 3100 細胞內放大器
產品特點:
l 方波發生器可測試電極電阻和電容補償
l 單個電極可同時刺激和記錄
l 低通和陷波濾波器
l 電極阻抗可測量
主要參數:
l Noise (10Hz - 50kHz): 18 μV, rms shorted; < 350 μV with 20 Megohm source
l Input impedance: 10^13 ohms; capacitance adjustable to zero
l Bias current: Adjustable to zero
l Voltage gain: x1 and x10
l Capacity Compensation: -4 pF - 35 pF
l DC Offset: ±1 V
l Max internal current: 1 μA
l External current: 100 nA/V; 10 V maximum
l Electrode test: 100 Hz, 10 nA; (i.e. 10 mV/Megohm electrode resistance)
l Ringer: 0 - 10 V biphasic, 2 - 8 kHz
引用案例:
l Suadicani SO et al. (2009) Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes. ASN Neuro 1(1):55-63
l Lowe GC, Luheshi GN, and Williams S (2008) Maternal infection and fever during late gestation are associated with altered synaptic transmission in the hippocampus of juvenile offspring rats. Am J Physiol Regul Integr Comp Physiol 295: R1563-R1571
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細胞外放大器

Model 1700四通道差分AC放大器

Model 1800雙通道微電極AC放大器
Model 1700/1800應用于可興奮組織(神經和肌肉等)細胞外神經電生理記錄,可記錄EMG/EEG/EKG/ERG,供教學和科研使用。Model 1800需連接轉換頭使用。
每通道放大器包含高增益低噪聲的差分電極并跟隨有低通、高通、陷波濾波器。每路還包含刺激電極,可在同一電極上發生刺激和記錄。
主要參數:
l Gain* x100, x1000, x10000
l High Pass Filter* 0.1, 1.0, 10, 100, and 300 Hz; -40 dB / decade
l Low Pass Filter* 500, 1000, 5000, 10000, and 20000 Hz; -40 dB / decade
l Notch Filter >-35dB at 50 or 60 Hz.(Model 1700)
l Notch Filter >-25dB at 50 or -30dB at 60 Hz.(Model 1800)
l Noise 1.0 microvolt p-p typical (10 Hz to 10,000 Hz)
l Common Mode Rejection > 80 dB
標*的參數可根據需要收費定制
引用案例:
l Chen FP and Evinger C (2006) Cerebellar modulation of trigeminal reflex blinks: Interpositus neurons. J Neuroscience 26(41):10569-10576
l Weiss SA, Preuss T, and Faber DS (2009) Phase encoding in the Mauthner system: Implications in left-right sound source discrimination. J euroscience 29(11)3431-3441
l Werk CM and Chapman CA (2003) Long-term potentiation of polysynaptic responses in layer V of the Sensorimotor Cortex induced by Theta-patterned tetanization in the awake rat. Cerebral Cortex 13(5): 500-507
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細胞外放大器

Model 3500 16通道差分AC放大器


Model 3600 16通道微電極AC放大器
Model 3500/3600應用于可興奮組織(神經和肌肉等)細胞外神經電生理記錄,可記錄EMG/EEG/EKG/ERG,供教學和科研使用。Model 3600需連接轉換頭使用。
該產品在傳統產品的基礎上,不僅提供更強大的參數配置功能,并且實驗參數還可通過觸屏或windows軟件控制。日志功能可提供實驗數據的時間戳方便數據的整理。
主要參數:
l Gain*: 10, 20, 50, 100, 200, 500, 1000, 2000, 5000,10000, 20000
l High Pass Filter* 0.3, 1.0, 3.0, 10, 30, 100, 300, and 500 Hz; -40 dB / decade
l Low Pass Filter* 0.1, 0.3, 0.5, 1.0, 3.0, 5.0, 10.0, and 20.0 kHz; -40 dB / decade
l Notch Filter >-35 dB at 50 or 60 Hz.
l Noise: 2.0 microvolt rms typical (10 Hz to 10,000 Hz)
標*的參數可根據需要收費定制
引用案例:
l Lu H, et al. (2007) Synchronized delta oscillations correlate with the resting-state functional MRI signal. PNAS 104 (46): 18265-18269
l Viggiano A., et al. (2010) Mastication overload causes an increase in O2- production into the subnucleus oralis of the spinal trigeminal nucleus Neuroscience 166(2):416-421
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刺激發生器

Model 3800 八路可編程刺激發生器
Model 3800 八路可編程刺激發生器應用非常廣泛。它高度靈活,可同時發生8路單相或兩相脈沖序列,此外,使用內置協議,可非常容易地發生步進脈沖或成對脈沖。
主要參數:
l Timing Rage: 1 μs to 250 Hours
l Minimum Pulse Duration: 1 μs monophasic; 2μs biphasic
l Minimum Pulse Interval: 1 μs monophasic; 2μs biphasic
l Timing Accuracy: Better than 0.02%
l Output: ± 10 V; ± 20 mA, with 1mV resolution
l With Optional SIU: ± 100 V; ±10 mA, with selectable AC coupling; 500kHz bandwidth
l Built-in Stimulus Protocols: Monophasic, Biphasic, Paired Pulse, and Stepped pulse
l Triggering: 8 Channel-specific rear panel BNCs; 3 non-specific front panel BNCs that can be assigned to any single or set of channels; Interchannel triggering
l Gating: 3 non-specific front panel BNCs that can be assigned to any single or set of channels; Interchannel gating
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刺激發生器


Model 4100 單通道高能可編程刺激發生器
Model 4100 是A-M Systems公司推出的功能最強大、使用最靈活的可編程刺激發生器,在各種場景得到廣泛應用。發生器可發生多種波形,并且用戶和通過自定義發生需要的波形。
典型應用:
l long-term potentiation (LTP)
l nerve conduction
l long-term depression (LTD)
l evoked potentials
l classical conditioning
l lesions
l field stimulation
l kindling / seizure models
主要參數:
l Amplitude: -200 V to 200 V @ 100 mA
l Minimum Event Width: 1 microsecond
l Maximum Event Width: 25 hours
l Minimum Event Interval: 2 microseconds
l Bandwidth: 1MHz
l Trigger Options: Manual, External, or Free-Run
l Software: Windows, OSx, Matlab, LabView, iOS, Android